- Information
- Symbol: TIP2,bHLH142
- MSU: LOC_Os01g18870
- RAPdb: Os01g0293100
- Publication
- The bHLH142 Transcription Factor Coordinates with TDR1 to Modulate the Expression of EAT1 and Regulate Pollen Development in Rice, 2014, Plant Cell.
- The Rice Basic Helix-Loop-Helix Transcription Factor TDR INTERACTING PROTEIN2 Is a Central Switch in Early Anther Development, 2014, Plant Cell.
- bHLH142 regulates various metabolic pathway-related genes to affect pollen development and anther dehiscence in rice., 2017, Sci Rep.
- Tightly Controlled Expression of bHLH142 Is Essential for Timely Tapetal Programmed Cell Death and Pollen Development in Rice., 2017, Front Plant Sci.
- Cloning, molecular evolution and functional characterization of ZmbHLH16, the maize ortholog of OsTIP2 OsbHLH142., 2017, Biol Open.
- OsMS188 Is a Key Regulator of Tapetum Development and Sporopollenin Synthesis in Rice, 2021, Rice (N Y).
- Genbank accession number
- Key message
- The Rice Basic Helix-Loop-Helix Transcription Factor TDR INTERACTING PROTEIN2 Is a Central Switch in Early Anther Development
- The tip2 mutants display undifferentiated inner three anther wall layers and abort tapetal programmed cell death, causing complete male sterility
- Thus, in this study, we identified bHLH142 as having a pivotal role in tapetal programmed cell death and pollen development.
- bHLH142 regulates various metabolic pathway-related genes to affect pollen development and anther dehiscence in rice.
- Overexpression of bHLH142 in transgenic rice resulted in indehiscent anthers and aborted pollen grains
- Overexpression of bHLH142 induced early expression of several key regulatory transcription factors in pollen development
- Tightly Controlled Expression of bHLH142 Is Essential for Timely Tapetal Programmed Cell Death and Pollen Development in Rice.
- We previously showed that knockout of bHLH142 in rice (Oryza sativa) causes pollen sterility by interrupting tapetal programmed cell death (PCD) and bHLH142 coordinates with TDR to modulate the expression of EAT1
- Thus, the findings of this study advance our understanding of the central role played by bHLH142 in the regulatory network leading to pollen development in rice and how overexpression of its expression affects pollen development
- In this study, we demonstrated that overexpression of bHLH142 (OE142) under the control of the ubiquitin promoter also leads to male sterility in rice by triggering the premature onset of PCD
- Exploitation of this novel functionality of bHLH142 may confer a big advantage to hybrid seed production
- UDT1, OsTDF1, TDR, bHLH142 and EAT1 are upstream regulators of rice tapetum development
- Connection
- TDR, TIP2~bHLH142, The Rice Basic Helix-Loop-Helix Transcription Factor TDR INTERACTING PROTEIN2 Is a Central Switch in Early Anther Development., We revealed that TIP2 acts upstream of TDR and EAT1 and directly regulates the expression of TDR and EAT1.
- DTD~EAT1, TIP2~bHLH142, The Rice Basic Helix-Loop-Helix Transcription Factor TDR INTERACTING PROTEIN2 Is a Central Switch in Early Anther Development., We revealed that TIP2 acts upstream of TDR and EAT1 and directly regulates the expression of TDR and EAT1.
- TDR, TIP2~bHLH142, The Rice Basic Helix-Loop-Helix Transcription Factor TDR INTERACTING PROTEIN2 Is a Central Switch in Early Anther Development., In addition, TIP2 can interact with TDR, indicating a role of TIP2 in later anther development.
- TIP2~bHLH142, Udt1, The bHLH142 Transcription Factor Coordinates with TDR1 to Modulate the Expression of EAT1 and Regulate Pollen Development in Rice, bHLH142 acts downstream of UDT1 and GAMYB but upstream of TDR1 and EAT1 in pollen development.
- AP37~OsERF3, TIP2~bHLH142, The bHLH142 Transcription Factor Coordinates with TDR1 to Modulate the Expression of EAT1 and Regulate Pollen Development in Rice, EAT1 positively regulates the expression of AP37 and AP25, which induce tapetal programmed cell death.
- DTD~EAT1, TIP2~bHLH142, Tightly Controlled Expression of bHLH142 Is Essential for Timely Tapetal Programmed Cell Death and Pollen Development in Rice., We previously showed that knockout of bHLH142 in rice (Oryza sativa) causes pollen sterility by interrupting tapetal programmed cell death (PCD) and bHLH142 coordinates with TDR to modulate the expression of EAT1
- TDR, TIP2~bHLH142, Tightly Controlled Expression of bHLH142 Is Essential for Timely Tapetal Programmed Cell Death and Pollen Development in Rice., We previously showed that knockout of bHLH142 in rice (Oryza sativa) causes pollen sterility by interrupting tapetal programmed cell death (PCD) and bHLH142 coordinates with TDR to modulate the expression of EAT1
- DTD~EAT1, TIP2~bHLH142, EAT1 transcription factor, a non-cell-autonomous regulator of pollen production, activates meiotic small RNA biogenesis in rice anther tapetum., The transient assay also demonstrated that UNDEVELOPED TAPETUM1 (UDT1)/bHLH164 is a potential interacting partner of both EAT1 and TIP2 during early meiosis
- DTD~EAT1, TIP2~bHLH142, EAT1 transcription factor, a non-cell-autonomous regulator of pollen production, activates meiotic small RNA biogenesis in rice anther tapetum., This study indicates that EAT1 is one of key regulators triggering meiotic phasiRNA biogenesis in anther tapetum, and that other bHLH proteins, TIP2 and UDT1, also play some important roles in this process
- PTC1~OsMS1, TIP2~bHLH142, OsMS1 functions as a transcriptional activator to regulate programmed tapetum development and pollen exine formation in rice., Y2H and BiFC assays demonstrated that OsMS1 can interact with OsMADS15 and TDR INTERACTING PROTEIN2 (TIP2)
- OsMYB80~BM1, TIP2~bHLH142, The MYB transcription factor Baymax1 plays a critical role in rice male fertility, BM1 can physically interacts with bHLH protein TIP2, EAT1, and PHD (plant homeodomain)-finger member TIP3, respectively
- TIP2~bHLH142, Udt1, OsMS188 Is a Key Regulator of Tapetum Development and Sporopollenin Synthesis in Rice, UDT1, OsTDF1, TDR, bHLH142 and EAT1 are upstream regulators of rice tapetum development
- OsTDF1, TIP2~bHLH142, OsMS188 Is a Key Regulator of Tapetum Development and Sporopollenin Synthesis in Rice, UDT1, OsTDF1, TDR, bHLH142 and EAT1 are upstream regulators of rice tapetum development
- TDR, TIP2~bHLH142, OsMS188 Is a Key Regulator of Tapetum Development and Sporopollenin Synthesis in Rice, UDT1, OsTDF1, TDR, bHLH142 and EAT1 are upstream regulators of rice tapetum development
- DTD~EAT1, TIP2~bHLH142, OsMS188 Is a Key Regulator of Tapetum Development and Sporopollenin Synthesis in Rice, UDT1, OsTDF1, TDR, bHLH142 and EAT1 are upstream regulators of rice tapetum development
- OsEDM2L, TIP2~bHLH142, OsEDM2L mediates m 6 A of EAT1 transcript for proper alternative splicing and polyadenylation regulating rice tapetal degradation, OsEDM2L interacts with the transcription factors bHLH142 and TAPETUM DEGENERATION RETARDATION to regulate the expression of ETERNAL TAPETUM 1 (EAT1), a positive regulator of tapetal PCD
- AMD1~PWA1, TIP2~bHLH142, POLLEN WALL ABORTION 1 is essential for pollen wall development in rice., PWA1 interacted with the transcription factor TAPETUM DEGENERATION RETARDATION (TDR)-INTERACTING PROTEIN2 (TIP2, also named bHLH142) in vivo and in vitro
- OsUGE1, TIP2~bHLH142, UDP-glucose epimerase 1, moonlighting as a transcriptional activator, is essential for tapetum degradation and male fertility in rice., Interestingly, we discovered that OsUGE1 participates in the TIP2/bHLH142-TDR-EAT1/DTD transcriptional regulatory cascade involved in tapetum degradation, in which TIP2 and TDR regulate the expression of OsUGE1 while OsUGE1 regulates the expression of EAT1
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