OsMLH1,PSSR1

• Symbol: OsMLH1,PSSR1
• MSU: LOC_Os01g72880
• RAPdb: Os01g0958900

• Rapid generation of rice mutants via the dominant negative suppression of the mismatch repair protein OsPMS1, 2012, Theor Appl Genet.
• Rice MutLγ, the MLH1-MLH3 heterodimer, participates in the formation of type I crossovers and regulation of embryo sac fertility, 2021, Plant Biotechnol J.
• OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice, 2021, J Genet Genomics.
• A retrotransposon insertion in MUTL-HOMOLOG 1 affects wild rice seed set and cultivated rice crossover rate., 2022, Plant Physiol.

Genbank accession number

• OsMLH3 and OsMLH1 (MutL-homolog 1) interact to form a heterodimer (MutL) to promote crossover formation in the macrospore and microspore mother cells and development of functional megaspore during meiosis, defective OsMLH3 or OsMLH1 in fsv1 and CRISPR/Cas9-based knockout lines results in reduced type I crossover and bivalent frequency
• OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice
• Here, we report the identification of OsMLH1 and reveal its functions during meiosis in rice
• A retrotransposon insertion in MUTL-HOMOLOG 1 affects wild rice seed set and cultivated rice crossover rate

• OsMLH1~PSSR1, OsMLH3, Rice MutLγ, the MLH1-MLH3 heterodimer, participates in the formation of type I crossovers and regulation of embryo sac fertility, OsMLH3 and OsMLH1 (MutL-homolog 1) interact to form a heterodimer (MutLγ) to promote crossover formation in the macrospore and microspore mother cells and development of functional megaspore during meiosis, defective OsMLH3 or OsMLH1 in fsv1 and CRISPR/Cas9-based knockout lines results in reduced type I crossover and bivalent frequency
• OsMLH1~PSSR1, OsMLH3, OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice, OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice
• OsMLH1~PSSR1, OsMLH3, OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice, OsMLH1 interacts with OsMLH3 through their C-terminal domains