LEPTO1,OsRR24,DLC1

• Symbol: LEPTO1,OsRR24,DLC1
• MSU: LOC_Os02g08500
• RAPdb: Os02g0182100

• The OsRR24/LEPTO1 Type-B Response Regulator is Essential for the Organization of Leptotene Chromosomes in Rice Meiosis., 2018, Plant Cell.
• Defective Leptotene Chromosome 1 DLC1 encodes a type-B response regulator and is required for rice meiosis., 2019, Plant J.
• Reproductive cells and peripheral parietal cells collaboratively participate in meiotic fate acquisition in rice anthers, 2021, Plant Journal.

Genbank accession number

• Although meiosis initiates normally, as indicated by staining of the centromere-specific histone CENH3, the meiotic chromosomes in lepto1 mutant pollen mother cells (PMCs) fail to form the thin thread-like structures that are typical of leptotene chromosomes in wild-type PMCs
• LEPTO1 is also essential for programmed cell death in tapetal cells
• Furthermore, lepto1 mutants fail to form chromosomal double-strand breaks, do not recruit meiosis-specific proteins to the meiotic chromosomes, and show disrupted callose deposition
• DLC1 is strongly expressed in the pollen mother cells (PMCs) and tapetum and encodes a nucleus-located rice type-B response regulator (RR) with transcriptional activity
• Further investigations show that DLC1 interacts with all five putative rice histidine phosphotransfer proteins (HPs) in yeast and planta cells, suggesting a possible participation of the two-component signalling systems (TCS) in rice meiosis
• Our results demonstrate that DLC1 is required for rice meiosis and fertility, providing useful information for the role of TCS in rice meiosis
• The dlc1 mutant is sterile in both male and female gametophytes due to an earlier defect in the leptotene chromosome and subsequent abnormalities at later stages

• CENH3~OsCENH3, LEPTO1~OsRR24~DLC1, The OsRR24/LEPTO1 Type-B Response Regulator is Essential for the Organization of Leptotene Chromosomes in Rice Meiosis., Although meiosis initiates normally, as indicated by staining of the centromere-specific histone CENH3, the meiotic chromosomes in lepto1 mutant pollen mother cells (PMCs) fail to form the thin thread-like structures that are typical of leptotene chromosomes in wild-type PMCs
• LEPTO1~OsRR24~DLC1, OHP1~OsAHP1, The OsRR24/LEPTO1 Type-B Response Regulator is Essential for the Organization of Leptotene Chromosomes in Rice Meiosis, LEPTO1 interacts with two authentic histidine phosphotransfer (AHP) proteins, OsAHP1 and OsAHP2, via the DDK domain, and a phosphomimetic mutation of the DDK domain relieves its repression of LEPTO1 transactivation activity.
• LEPTO1~OsRR24~DLC1, OHP2~OsAHP2, The OsRR24/LEPTO1 Type-B Response Regulator is Essential for the Organization of Leptotene Chromosomes in Rice Meiosis, LEPTO1 interacts with two authentic histidine phosphotransfer (AHP) proteins, OsAHP1 and OsAHP2, via the DDK domain, and a phosphomimetic mutation of the DDK domain relieves its repression of LEPTO1 transactivation activity.