OsCDC48

• Symbol: OsCDC48
• MSU: LOC_Os03g05730
• RAPdb: Os03g0151800

• Single base substitution in OsCDC48 is responsible for premature senescence and death phenotype in rice., 2015, J Integr Plant Biol.
• OsCDC48/48E complex is required for plant survival in rice Oryza sativa L.., 2019, Plant Mol Biol.

Genbank accession number

• OsCDC48 was expressed constitutively in the root, stem, leaf and panicle
• Single base substitution in OsCDC48 is responsible for premature senescence and death phenotype in rice.
• Our results indicated that the impaired function of OsCDC48 was responsible for the premature senescence and death phenotype
• Overexpression of OsCDC48-psd128 resulted in differential expression of AAA-ATPase associated genes leading to increased total ATPase activity, accumulation of reactive oxygen species and decreased plant tiller numbers while overexpression of OsCDC48 also resulted in differential expression of AAA-ATPase associated genes leading to increased total ATPase activity, but increased plant tiller numbers and grain yield, indicating its potential utilization for yield improvement
• We demonstrate that the C-terminus of OsCDC48 is essential for maintaining its full ATPase activity and OsCDC48/48E interaction is required to modulate cellular processes and plant survival in rice
• Our results demonstrated that the C-terminal region of OsCDC48 was essential for maintaining the full ATPase activity and OsCDC48/48E complex might function in form of heteromultimers to modulate cellular processes and plant survival in rice
• Removal of the C-terminus of OsCDC48 caused altered expression of cell cycle-related genes, changed the percentage of cells in G1 and G2/M phases, and abolished the interaction between OsCDC48 itself and between OsCDC48 and OsCDC48E, respectively

• OsCDC48, OsDER1, OsDER1 is an ER-associated protein degradation factor that responds to ER stress., Coimmunoprecipitation experiments demonstrated that OsDER1 interacted with OsHRD1, OsHRD3, and OsCDC48, the essential components of the canonical ERAD pathway
• G1, OsCDC48, OsCDC48/48E complex is required for plant survival in rice Oryza sativa L.., Removal of the C-terminus of OsCDC48 caused altered expression of cell cycle-related genes, changed the percentage of cells in G1 and G2/M phases, and abolished the interaction between OsCDC48 itself and between OsCDC48 and OsCDC48E, respectively
• OsCDC48, OsCDC48E, OsCDC48/48E complex is required for plant survival in rice Oryza sativa L.., Here, we showed that OsCDC48 (Os03g0151800) interacted with OsCDC48E (Os10g0442600), a homologue of OsCDC48, to control plant survival in rice
• OsCDC48, OsCDC48E, OsCDC48/48E complex is required for plant survival in rice Oryza sativa L.., Removal of the C-terminus of OsCDC48 caused altered expression of cell cycle-related genes, changed the percentage of cells in G1 and G2/M phases, and abolished the interaction between OsCDC48 itself and between OsCDC48 and OsCDC48E, respectively