OsHDAC1

2015-01-20 | Categories genes  | Tags growth  root  seedling  architecture  breeding  lateral root 

• Information
  • Symbol: OsHDAC1
  • MSU: LOC_Os06g38470
  • RAPdb: Os06g0583400
• Publication
  • Structure and expression of the rice class-I type histone deacetylase genesOsHDAC1-3:OsHDAC1overexpression in transgenic plants leads to increased growth rate and altered architecture, 2003, The Plant Journal.
  • The histone deacetylase OsHDAC1 epigenetically regulates theOsNAC6gene that controls seedling root growth in rice, 2009, The Plant Journal.
  • Histone deacetylase HDA710 controls salt tolerance by regulating ABA signaling in rice, 2020, J Integr Plant Biol.
  • The Histone Deacetylase 1/ GSK3/SHAGGY-Like Kinase 2/ BRASSINAZOLE RESISTANT 1 Module Controls Lateral Root Formation in Rice., 2022, Plant Physiol.
• Genbank accession number
  • AF513382
• Key message
  • The overexpression leads to a range of novel phenotypes, involving increased growth rate and altered plant architecture, suggesting that OsHDAC1 functions in the genome-wide programming of gene expression
  • Structure and expression of the rice class-I type histone deacetylase genesOsHDAC1-3:OsHDAC1overexpression in transgenic plants leads to increased growth rate and altered architecture
  • We have previously isolated a rice gene encoding a histone deacetylase, OsHDAC1, and observed that its transgenic overexpression increases seedling root growth
  • To identify the transcriptional repression events that occur as a result of OsHDAC1 overexpression (OsHDAC1(OE)), a global profiling of root-expressed genes was performed on OsHDAC1(OE) or HDAC inhibitor-treated non-transgenic (NT) roots, in comparison with untreated NT roots
  • We selected 39 genes that are induced and repressed in HDAC inhibitor-treated NT and OsHDAC1(OE) roots, compared with NT roots, respectively
  • The root phenotype of OsNAC6 knock-out seedlings was observed to be similar to that of the OsHDAC1(OE) seedlings
  • Conversely, the root phenotype of the OsNAC6 overexpressors was similar to that of the OsHDAC1 knock-out seedlings
  • These observations indicate that OsHDAC1 negatively regulates the OsNAC6 gene that primarily mediates the alteration in the root growth of the OsHDAC1(OE) seedlings
  • The histone deacetylase OsHDAC1 epigenetically regulates theOsNAC6gene that controls seedling root growth in rice
  • OsHDAC1 was expressed at similar levels in the leaves, roots, and callus cells, whereas OsHDAC2 and 3 were expressed in the roots and callus cells, but not in the leaves, exhibiting distinct tissue specificity
  • Rice OsHDAC1 RNAi plants produced fewer lateral roots than wild-type plants, whereas plants overexpressing OsHDAC1 exhibited increased lateral root proliferation by promoting LR primordia formation
  • Our findings suggest that OsHDAC1 is a breeding target in rice that can improve resource capture
• Connection
  • OsHDAC1, OsNAC6~SNAC2, The histone deacetylase OsHDAC1 epigenetically regulates theOsNAC6gene that controls seedling root growth in rice, Interestingly, OsNAC6, a member of the NAM-ATAF-CUC (NAC) family, was identified as a key component of the OsHDAC1 regulon, and was found to be epigenetically repressed by OsHDAC1 overexpression
  • OsHDAC1, OsNAC6~SNAC2, The histone deacetylase OsHDAC1 epigenetically regulates theOsNAC6gene that controls seedling root growth in rice, The root phenotype of OsNAC6 knock-out seedlings was observed to be similar to that of the OsHDAC1(OE) seedlings
  • OsHDAC1, OsNAC6~SNAC2, The histone deacetylase OsHDAC1 epigenetically regulates theOsNAC6gene that controls seedling root growth in rice, Conversely, the root phenotype of the OsNAC6 overexpressors was similar to that of the OsHDAC1 knock-out seedlings
  • OsHDAC1, OsNAC6~SNAC2, The histone deacetylase OsHDAC1 epigenetically regulates theOsNAC6gene that controls seedling root growth in rice, These observations indicate that OsHDAC1 negatively regulates the OsNAC6 gene that primarily mediates the alteration in the root growth of the OsHDAC1(OE) seedlings
  • OsHDAC1, OsNAC6~SNAC2, The histone deacetylase OsHDAC1 epigenetically regulates theOsNAC6gene that controls seedling root growth in rice, Chromatin immunoprecipitation assays of the OsNAC6 promoter region using antibodies specific to acetylated histones H3 and H4 revealed that OsHDAC1 epigenetically represses the expression of OsNAC6 by deacetylating K9, K14 and K18 on H3 and K5, K12 and K16 on H4
  • OsHDAC1, OsNAC6~SNAC2, The histone deacetylase OsHDAC1 epigenetically regulates theOsNAC6gene that controls seedling root growth in rice, The histone deacetylase OsHDAC1 epigenetically regulates theOsNAC6gene that controls seedling root growth in rice
  • GSK2~OsGSK2~OsSK22, OsHDAC1, The Histone Deacetylase 1/ GSK3/SHAGGY-Like Kinase 2/ BRASSINAZOLE RESISTANT 1 Module Controls Lateral Root Formation in Rice., Importantly, OsHDAC1 could directly interact with and deacetylate OsGSK2, inhibiting its activity
  • GSK2~OsGSK2~OsSK22, OsHDAC1, The Histone Deacetylase 1/ GSK3/SHAGGY-Like Kinase 2/ BRASSINAZOLE RESISTANT 1 Module Controls Lateral Root Formation in Rice., Taken together, the results indicate that OsHDAC1 regulates LR formation in rice by deactivating OsGSK2, thereby preventing degradation of OsBZR1, a positive regulator of LR primordia formation
  • OsBZR1~BZR1, OsHDAC1, The Histone Deacetylase 1/ GSK3/SHAGGY-Like Kinase 2/ BRASSINAZOLE RESISTANT 1 Module Controls Lateral Root Formation in Rice., Taken together, the results indicate that OsHDAC1 regulates LR formation in rice by deactivating OsGSK2, thereby preventing degradation of OsBZR1, a positive regulator of LR primordia formation

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