SPIN6

• Symbol: SPIN6
• MSU: LOC_Os07g46450
• RAPdb: Os07g0658300

• The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice., 2015, PLoS Pathog.

Genbank accession number

• Both RNAi silencing in transgenic rice and knockout of Spin6 in a T-DNA insertion mutant lead to PCD and increased resistance to the rice blast pathogen Magnaporthe oryzae and the bacterial blight pathogen Xanthomonas oryzae pv
• The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice.
• Together, our results demonstrate that the RhoGAP SPIN6 acts as a linkage between a U-box E3 ligase-mediated ubiquitination pathway and a small GTPase-associated defensome system for plant immunity
• The levels of reactive oxygen species and defense-related gene expression are significantly elevated in both the Spin6 RNAi and mutant plants

• OsRac1, SPIN6, The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice., The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice.
• OsRac1, SPIN6, The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice., Strikingly, SPIN6 interacts with the small GTPase OsRac1, catalyze the GTP-bound OsRac1 into the GDP-bound state in vitro and has GAP activity towards OsRac1 in rice cells
• SPIN6, SPL11, The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice., The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice.
• SPIN6, SPL11, The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice., In this study, we report that SPL11-interacting Protein 6 (SPIN6) is a Rho GTPase-activating protein (RhoGAP) that interacts with SPL11 in vitro and in vivo
• SPIN6, SPL11, The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice., SPL11 ubiquitinates SPIN6 in vitro and degrades SPIN6 in vivo via the 26S proteasome-dependent pathway
• OsHUB1~MIP1, SPIN6, OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice., OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice.
• OsHUB1~MIP1, SPIN6, OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice., Here, we show that SPIN6 interacts with OsHUB1 and OsHUB2, the homologous proteins of Arabidopsis RING finger E3 ligases HUB1 and HUB2
• OsHUB1~MIP1, SPIN6, OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice., OsHub1 and OsHub2 are down-regulated in the Spin6 RNAi plants and during the compatible interaction between rice and Magnaporthe oryzae
• OsHUB2~FRRP1, SPIN6, OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice., OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice.
• OsHUB2~FRRP1, SPIN6, OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice., Here, we show that SPIN6 interacts with OsHUB1 and OsHUB2, the homologous proteins of Arabidopsis RING finger E3 ligases HUB1 and HUB2
• OsHUB2~FRRP1, SPIN6, OsHUB1 and OsHUB2 interact with SPIN6 and form homo- and hetero-dimers in rice., OsHub1 and OsHub2 are down-regulated in the Spin6 RNAi plants and during the compatible interaction between rice and Magnaporthe oryzae