OsDWD1

• Symbol: OsDWD1
• MSU: LOC_Os09g19900
• RAPdb: Os09g0363600

• OsDWD1 E3 ligase-mediated OsNPR1 degradation suppresses basal defense in rice., 2022, Plant J.

Genbank accession number

• After constructing the loss-of-function mutant OsDWD1(R239A) , we showed that the downregulation of OsNPR1 seen in rice lines overexpressing wild-type (WT) OsDWD1 (OsDWD1(WT) -ox) was compromised in OsDWD1(R239A) -ox lines, and that OsNPR1 upregulation enhanced resistance to pathogen infection, confirming that OsCRL4(OsDWD1) regulates OsNPR1 protein levels
• The enhanced disease resistance seen in OsDWD1 knock-down (OsDWD1-kd) lines contrasted with the reduced disease resistance in double knock-down (OsDWD1/OsNPR1-kd) lines, indicating that the enhanced disease resistance of OsDWD1-kd resulted from the accumulation of OsNPR1
• OsDWD1 E3 ligase-mediated OsNPR1 degradation suppresses basal defense in rice.
• Knock-down and overexpression experiments in rice plants showed that OsDWD1 is a negative regulator of the immune response and that OsNPR1 is a substrate of OsDWD1 and a substrate receptor of OsCRL4
• Taken together, these results indicate that OsDWD1 regulates OsNPR1 protein levels in rice to suppress the untimely activation of immune responses

• OsDWD1, OsNPR1~NH1, OsDWD1 E3 ligase-mediated OsNPR1 degradation suppresses basal defense in rice., OsDWD1 E3 ligase-mediated OsNPR1 degradation suppresses basal defense in rice.
• OsDWD1, OsNPR1~NH1, OsDWD1 E3 ligase-mediated OsNPR1 degradation suppresses basal defense in rice., Knock-down and overexpression experiments in rice plants showed that OsDWD1 is a negative regulator of the immune response and that OsNPR1 is a substrate of OsDWD1 and a substrate receptor of OsCRL4
• OsDWD1, OsNPR1~NH1, OsDWD1 E3 ligase-mediated OsNPR1 degradation suppresses basal defense in rice., After constructing the loss-of-function mutant OsDWD1(R239A) , we showed that the downregulation of OsNPR1 seen in rice lines overexpressing wild-type (WT) OsDWD1 (OsDWD1(WT) -ox) was compromised in OsDWD1(R239A) -ox lines, and that OsNPR1 upregulation enhanced resistance to pathogen infection, confirming that OsCRL4(OsDWD1) regulates OsNPR1 protein levels
• OsDWD1, OsNPR1~NH1, OsDWD1 E3 ligase-mediated OsNPR1 degradation suppresses basal defense in rice., The enhanced disease resistance seen in OsDWD1 knock-down (OsDWD1-kd) lines contrasted with the reduced disease resistance in double knock-down (OsDWD1/OsNPR1-kd) lines, indicating that the enhanced disease resistance of OsDWD1-kd resulted from the accumulation of OsNPR1
• OsDWD1, OsNPR1~NH1, OsDWD1 E3 ligase-mediated OsNPR1 degradation suppresses basal defense in rice., Taken together, these results indicate that OsDWD1 regulates OsNPR1 protein levels in rice to suppress the untimely activation of immune responses