OsMYC2

• Symbol: OsMYC2
• MSU: LOC_Os10g42430
• RAPdb: Os10g0575000

• Jasmonic acid regulates spikelet development in rice, 2014, Nature Communications.
• Overexpression of OsMYC2 Results in the Up-Regulation of Early JA-Rresponsive Genes and Bacterial Blight Resistance in Rice., 2016, Plant Cell Physiol.
• OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability., 2017, Sci Rep.
• OsMYC2 mediates numerous defence-related transcriptional changes via jasmonic acid signalling in rice., 2017, Biochem Biophys Res Commun.
• Identification of OsMYC2-regulated senescence-associated genes in rice., 2017, Planta.
• Rice MYC2 OsMYC2 modulates light-dependent seedling phenotype, disease defence but not ABA signalling., 2017, J Biosci.
• OsJAZ13 Negatively Regulates Jasmonate Signaling and Activates Hypersensitive Cell Death Response in Rice, 2020, Int J Mol Sci..
• Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice, 2020, PLoS Pathog.
• Magnaporthe oryzae systemic defense trigger 1 MoSDT1-mediated metabolites regulate defense response in Rice, 2021, BMC Plant Biol.
• OsPHR2 modulates phosphate starvation-induced OsMYC2 signaling and resistance to Xanthomonas oryzae pv. oryzae , 2021, Plant Cell Environ.
• Rice MEDIATOR25, OsMED25, is an essential subunit for jasmonate-mediated root development and OsMYC2-mediated leaf senescence , 2021, Plant Sci.
• Warm temperature compromises JA-regulated basal resistance to enhance Magnaporthe oryzae infection in rice., 2022, Mol Plant.

Genbank accession number

• OsJAZ1 also interacts with OsMYC2, a transcription factor in the JA signalling pathway, and represses OsMYC2’s role in activating OsMADS1, an E-class gene crucial to the spikelet development.
• Overexpression of OsMYC2 Results in the Up-Regulation of Early JA-Rresponsive Genes and Bacterial Blight Resistance in Rice.
• Overall, we conclude that OsMYC2 acts as a positive regulator of early JA signals in the JA-induced resistance against Xoo in rice
• The up-regulation of OsMYC2 in response to JA was regulated by OsJAZ8
• Transgenic rice plants overexpressing OsMYC2 exhibited a JA-hypersensitive phenotype and were more resistant to Xoo
• Our results indicate that JA signalling via OsMYC2 is reinforced by OsMYL1 and OsMYL2, resulting in the inductive production of sakuranetin during defence responses in rice
• Furthermore, a substantial change was noted in the expression of distinct types of transcription factors, such as MYB-type factors, likely depicting the importance of OsMYC2 in not only defence responses but also other morphogenetic events
• OsMYC2 mediates numerous defence-related transcriptional changes via jasmonic acid signalling in rice.
• The jasmonic acid (JA)-responsive transcription factor OsMYC2 acts as a positive regulator of leaf senescence by direct regulation of some senescence-associated genes in rice
• Here, we report that OsMYC2 plays an important role in leaf senescence under dark-induced senescence (DIS) conditions
• Overexpression of OsMYC2 significantly promoted leaf senescence, indicated by reduction of chlorophyll content under DIS conditions in rice
• These results suggest that OsMYC2 acts as a positive regulator of leaf senescence by direct- or indirect-regulation of SAGs in rice
• In agreement with AtMYC2 function, OsMYC2 over-expression and RNAi lines showed enhanced and suppressed seedling growth compared to WT plants respectively under blue light, and showed little effect under white light or dark
• However, the role of OsMYC2 in seedling development under ABA, dark or light of specific wavelengths was not known
• However, in contrast to AtMYC2 function, OsMYC2 influences seedling development under red light and show no effect in ABA-mediated seed germination
• Moreover, the enhancement of RSV resistance conferred by BR is impaired in OsMYC2 (a key positive regulator of JA response) knockout plants, suggesting that BR-mediated RSV resistance requires active JA pathway
• OsGSK2 physically interacts with OsMYC2, resulting in the degradation of OsMYC2 by phosphorylation and reduces JA-mediated defense to facilitate virus infection
• OsPHR2 modulates phosphate starvation-induced OsMYC2 signaling and resistance to Xanthomonas oryzae pv. oryzae
• Here, we report that Pi starvation in rice activates the OsMYC2 signaling and enhances resistance to Xanthomonas oryzae pv
• Molecular analyses and infection studies using OsPHR2-Ov1 and phr2 mutants further demonstrated that OsPHR2 enhances antibacterial resistance via transcriptional regulation of OsMYC2 expression, indicating a positive role of OsPHR2-OsMYC2 crosstalk in modulating the OsMYC2 signaling and Xoo infection
• Genetic analysis and infection assays using myc2 mutants revealed that Pi starvation-induced OsMYC2 signaling activation and consequent Xoo resistance depends on the regulation of OsMYC2

• OsJAZ1~OsTIFY3~EG2, OsMYC2, Jasmonic acid regulates spikelet development in rice, OsJAZ1 also interacts with OsMYC2, a transcription factor in the JA signalling pathway, and represses OsMYC2’s role in activating OsMADS1, an E-class gene crucial to the spikelet development.
• OsLG3b~OsMADS1~LHS1~AFO, OsMYC2, Jasmonic acid regulates spikelet development in rice, OsJAZ1 also interacts with OsMYC2, a transcription factor in the JA signalling pathway, and represses OsMYC2’s role in activating OsMADS1, an E-class gene crucial to the spikelet development.
• OsJAZ8~OsTIFY10c, OsMYC2, Overexpression of OsMYC2 Results in the Up-Regulation of Early JA-Rresponsive Genes and Bacterial Blight Resistance in Rice., The up-regulation of OsMYC2 in response to JA was regulated by OsJAZ8
• OsJAZ10~OsTIFY11b, OsMYC2, Overexpression of OsMYC2 Results in the Up-Regulation of Early JA-Rresponsive Genes and Bacterial Blight Resistance in Rice., A large-scale microarray analysis revealed that OsMYC2 up-regulated OsJAZ10 as well as many other defense-related genes
• OsJAZ10~OsTIFY11b, OsMYC2, Overexpression of OsMYC2 Results in the Up-Regulation of Early JA-Rresponsive Genes and Bacterial Blight Resistance in Rice., OsMYC2 selectively bound to the G-box-like motif of the OsJAZ10 promoter in vivo and regulated the expression of early JA-responsive genes, but not of late JA-responsive genes
• OsMYC2, OsMYL2, OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability., In addition, we identified 2 collaborators of OsMYC2, OsMYC2-like protein 1 and 2 (OsMYL1 and OsMYL2) that further activated the OsNOMT promoter in synergy with OsMYC2
• OsMYC2, OsMYL2, OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability., Physical interaction of OsMYC2 with OsMYL1 and OsMYL2 further supported the idea that these interactions lead to the enhancement of the transactivation activity of OsMYC2
• OsMYC2, OsMYL2, OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability., Our results indicate that JA signalling via OsMYC2 is reinforced by OsMYL1 and OsMYL2, resulting in the inductive production of sakuranetin during defence responses in rice
• OsMYC2, OsNOMT, OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability., In this study, we show that JA-inducible basic helix-loop-helix transcriptional factor OsMYC2 drastically enhances the activity of the OsNOMT promoter and is essential for JA-inducible sakuranetin production
• OsMYC2, OsNOMT, OsMYC2, an essential factor for JA-inductive sakuranetin production in rice, interacts with MYC2-like proteins that enhance its transactivation ability., In addition, we identified 2 collaborators of OsMYC2, OsMYC2-like protein 1 and 2 (OsMYL1 and OsMYL2) that further activated the OsNOMT promoter in synergy with OsMYC2
• OsMYC2, OsNINJA1, Overexpression of OsNINJA1 negatively affects a part of OsMYC2-mediated abiotic and biotic responses in rice., In this study, we found that OsNINJA1, which is a JAZ-interacting adaptor protein, plays an important role in JA signaling that is positively regulated by the transcription factor OsMYC2 in rice
• OsMYC2, OsSRO1a~TWI1, The overexpression of OsSRO1a, which encodes an OsNINJA1- and OsMYC2-interacting protein, negatively affects OsMYC2-mediated jasmonate signaling in rice., OsNINJA1-interacting protein, OsSRO1a, acts as a mediator that suppresses OsMYC2 activity in response to JA
• OsMYC2, OsSRO1a~TWI1, The overexpression of OsSRO1a, which encodes an OsNINJA1- and OsMYC2-interacting protein, negatively affects OsMYC2-mediated jasmonate signaling in rice., OsSRO1a also interacted with OsMYC2, a positive transcription factor in JA signaling, in both plant and yeast cells
• OsCOI1~OsCOI1a, OsMYC2, OsJAZ13 Negatively Regulates Jasmonate Signaling and Activates Hypersensitive Cell Death Response in Rice, Yeast two-hybrid assays revealed OsJAZ13a directly interacts with OsMYC2, and also with OsCOI1, in a COR-dependent manner
• GSK2~OsGSK2~OsSK22, OsMYC2, Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice, OsGSK2 physically interacts with OsMYC2, resulting in the degradation of OsMYC2 by phosphorylation and reduces JA-mediated defense to facilitate virus infection
• OsMYC2, OsRap2.6~OsERF101, Rice ETHYLENE RESPONSE FACTOR 101 Promotes Leaf Senescence Through Jasmonic Acid-Mediated Regulation of OsNAP and OsMYC2, Transient transactivation and chromatin immunoprecipitation assays revealed that OsERF101 directly binds to the promoter regions of OsNAP and OsMYC2, which activate genes involved in chlorophyll degradation and JA signaling-mediated leaf senescence
• OsMYC2, OsPHR2, OsPHR2 modulates phosphate starvation-induced OsMYC2 signaling and resistance to Xanthomonas oryzae pv. oryzae , OsPHR2 modulates phosphate starvation-induced OsMYC2 signaling and resistance to Xanthomonas oryzae pv. oryzae
• OsMYC2, OsPHR2, OsPHR2 modulates phosphate starvation-induced OsMYC2 signaling and resistance to Xanthomonas oryzae pv. oryzae , The direct regulation of OsPHR2 on the OsMYC2 promoter was confirmed by yeast one-hybrid, electrophoretic mobility shift, dual-luciferase, and chromatin immunoprecipitation assays
• OsMYC2, OsPHR2, OsPHR2 modulates phosphate starvation-induced OsMYC2 signaling and resistance to Xanthomonas oryzae pv. oryzae , Molecular analyses and infection studies using OsPHR2-Ov1 and phr2 mutants further demonstrated that OsPHR2 enhances antibacterial resistance via transcriptional regulation of OsMYC2 expression, indicating a positive role of OsPHR2-OsMYC2 crosstalk in modulating the OsMYC2 signaling and Xoo infection
• OsMED25, OsMYC2, Rice MEDIATOR25, OsMED25, is an essential subunit for jasmonate-mediated root development and OsMYC2-mediated leaf senescence, Mutated osmed25 protein could not interact with OsMYC2, which is a positive TF in JA signaling in rice
• OsMED25, OsMYC2, Rice MEDIATOR25, OsMED25, is an essential subunit for jasmonate-mediated root development and OsMYC2-mediated leaf senescence , Mutated osmed25 protein could not interact with OsMYC2, which is a positive TF in JA signaling in rice
• OsMYB22, OsMYC2, Warm temperature compromises JA-regulated basal resistance to enhance Magnaporthe oryzae infection in rice., Among these affected genes, OsCEBiP (chitin elicitor-binding protein precursor) was found to be directly regulated by OsMYB22 and its interacting protein OsMYC2, a key component of JA signaling, and this contributed to temperature-modulated blast resistance
• OsAOC~OsAOC1, OsMYC2, Warm temperature compromises JA-regulated basal resistance to enhance Magnaporthe oryzae infection in rice., Phenotypic analyses of the osaoc1 and osmyc2 mutants, OsCOI1 RNAi lines, and OsMYC2-OE plants further demonstrated that compromised M
• CEBiP~OsCEBiP, OsMYC2, Warm temperature compromises JA-regulated basal resistance to enhance Magnaporthe oryzae infection in rice., Among these affected genes, OsCEBiP (chitin elicitor-binding protein precursor) was found to be directly regulated by OsMYB22 and its interacting protein OsMYC2, a key component of JA signaling, and this contributed to temperature-modulated blast resistance
• OsCOI1~OsCOI1a, OsMYC2, Warm temperature compromises JA-regulated basal resistance to enhance Magnaporthe oryzae infection in rice., Phenotypic analyses of the osaoc1 and osmyc2 mutants, OsCOI1 RNAi lines, and OsMYC2-OE plants further demonstrated that compromised M
• OsMED25, OsMYC2, The Mutation of Rice MEDIATOR25, OsMED25, Induces Rice Bacterial Blight and Auxin-Signaling., The expression of JA-responsive defense-related genes regulated by OsMYC2, which is a positive TF in JA signaling, was downregulated in osmed25 mutants
• CslF6~OsCslF6, OsMYC2, Poaceae-specific β-1,3;1,4-d-glucans link jasmonate signalling to OsLecRK1-mediated defence response during rice-brown planthopper interactions., OsMYC2, a master transcription factor of jasmonate signalling, directly controlled the upregulation of OsCslF6 in response to BPH feeding
• OsJAZ10~OsTIFY11b, OsMYC2, Hydrogen peroxide regulates the Osa-miR156-OsSPL2/OsTIFY11b module in rice., Furthermore, OsTIFY11b interacted with OsMYC2 to regulate the expression of OsRBBI3-3, which encodes a proteinase inhibitor