- Information
- Symbol: OsMKK4,LARGE11
- MSU: LOC_Os02g54600
- RAPdb: Os02g0787300
- Publication
- Arsenic stress activates MAP kinase in rice roots and leaves, 2011, Arch Biochem Biophys.
- The bHLH Rac Immunity1 RAI1 Is Activated by OsRac1 via OsMAPK3 and OsMAPK6 in Rice Immunity, 2012, Plant Cell Physiol.
- SMALL GRAIN 1, which encodes a mitogen-activated protein kinase kinase 4, influences grain size in rice, 2014, Plant J.
- Involvement of the OsMKK4-OsMPK1 Cascade and its Downstream Transcription Factor OsWRKY53 in the Wounding Response in Rice, 2014, Plant Pathol J.
- Control of grain size and weight by the OsMKKK10-OsMKK4-OsMAPK6 signaling pathway in rice., 2018, Mol Plant.
- ERECTA1 Acts Upstream of the OsMKKK10-OsMKK4-OsMPK6 Cascade to Control Spikelet Number by Regulating Cytokinin Metabolism in Rice , 2020, plant cell.
- OrMKK3 Influences Morphology and Grain Size in Rice, 2021, J Plant Biol.
- Genbank accession number
- Key message
- Further results revealed that OsMKK4 influenced brassinosteroid (BR) responses and the expression of BR-related genes
- Among MAPK kinase (MKKs) gene family, OsMKK4 transcripts were found to be induced in arsenite treated rice leaves and roots
- Thus, our findings have identified OsMKK4 as a factor for grain size, and suggest a possible link between the MAPK pathways and BRs in grain growth
- Involvement of the OsMKK4-OsMPK1 Cascade and its Downstream Transcription Factor OsWRKY53 in the Wounding Response in Rice
- Taken together, components involving in the wounding signaling pathway, OsMKK4-OsMPK1-OsWRKY53, can be important players in regulating crosstalk between abiotic stress and biotic stress.
- Further biochemical and genetic analyses reveal that OsMKKK10, OsMKK4 and OsMAPK6 function in a common pathway to control grain size
- OsMKK4A227T encoded by the large11-1D allele has stronger kinase activity than OsMKK4
- Connection
- OsMKK4~LARGE11, OsMPK1~OsMAPK6~OsSIPK, The bHLH Rac Immunity1 RAI1 Is Activated by OsRac1 via OsMAPK3 and OsMAPK6 in Rice Immunity, Overexpression of OsMAPK6 and/or OsMAPK3 together with OsMKK4-dd increased PAL1 and OsWRKY19 expression in rice protoplasts
- OsMKK4~LARGE11, RAI1, The bHLH Rac Immunity1 RAI1 Is Activated by OsRac1 via OsMAPK3 and OsMAPK6 in Rice Immunity, Also, RAI1 was phosphorylated by OsMAPK3/6 and OsMKK4-dd in vitro
- OsMKK4~LARGE11, RAI1, The bHLH Rac Immunity1 RAI1 Is Activated by OsRac1 via OsMAPK3 and OsMAPK6 in Rice Immunity, Therefore, the regulation of PAL1 and OsWRKY19 expression by RAI1 could be controlled via an OsMKK4-OsMAPK3/6 cascade
- OsMKK4~LARGE11, OsMPK1~OsMAPK6~OsSIPK, Involvement of the OsMKK4-OsMPK1 Cascade and its Downstream Transcription Factor OsWRKY53 in the Wounding Response in Rice, Further analysis revealed that OsMKK4, the upstream kinase of OsMPK1, phosphorylated OsMPK1 by wounding in vivo.
- OsMKK4~LARGE11, OsMPK1~OsMAPK6~OsSIPK, OsMAPK6, a mitogen-activated protein kinase, influences rice grain size and biomass production, As a functional kinase, OsMAPK6 interacts strongly with OsMKK4, indicating that OsMKK4 is likely to be the upstream MAPKK of OsMAPK6 in rice.
- OsMKK4~LARGE11, OsMKP1~GSN1~LARGE8~GLA1, GRAIN SIZE AND NUMBER1 Negatively Regulates the OsMKKK10-OsMKK4-OsMPK6 Cascade to Coordinate the Trade-off between Grain Number per Panicle and Grain Size in Rice., Consistent with this finding, the suppression of mitogen-activated protein kinase genes OsMPK6, OsMKK4, and OsMKKK10 separately resulted in denser panicles and smaller grains, which rescued the mutant gsn1 phenotypes
- OsMKK4~LARGE11, YDA1~SMG2~OsMKKK10, Control of grain size and weight by the OsMKKK10-OsMKK4-OsMAPK6 signaling pathway in rice., OsMKKK10 interacts with and phosphorylates OsMKK4
- OsMKK4~LARGE11, YDA1~SMG2~OsMKKK10, Control of grain size and weight by the OsMKKK10-OsMKK4-OsMAPK6 signaling pathway in rice., Further biochemical and genetic analyses reveal that OsMKKK10, OsMKK4 and OsMAPK6 function in a common pathway to control grain size
- OsMKK4~LARGE11, OsMPK1~OsMAPK6~OsSIPK, Control of grain size and weight by the OsMKKK10-OsMKK4-OsMAPK6 signaling pathway in rice., Further biochemical and genetic analyses reveal that OsMKKK10, OsMKK4 and OsMAPK6 function in a common pathway to control grain size
- OsER1, OsMKK4~LARGE11, ERECTA1 Acts Upstream of the OsMKKK10-OsMKK4-OsMPK6 Cascade to Control Spikelet Number by Regulating Cytokinin Metabolism in Rice , Furthermore, overexpression of either DST or OsCKX2 rescued the spikelet number phenotype of the oser1, osmkkk10, osmkk4, and osmpk6 mutants, suggesting that the DST-OsCKX2 module genetically functions downstream of the OsER1-OsMKKK10-OsMKK4-OsMPK6 pathway
- OsMKK4~LARGE11, YDA1~SMG2~OsMKKK10, ERECTA1 Acts Upstream of the OsMKKK10-OsMKK4-OsMPK6 Cascade to Control Spikelet Number by Regulating Cytokinin Metabolism in Rice , Furthermore, overexpression of either DST or OsCKX2 rescued the spikelet number phenotype of the oser1, osmkkk10, osmkk4, and osmpk6 mutants, suggesting that the DST-OsCKX2 module genetically functions downstream of the OsER1-OsMKKK10-OsMKK4-OsMPK6 pathway
- DST~WL1~HST1, OsMKK4~LARGE11, ERECTA1 Acts Upstream of the OsMKKK10-OsMKK4-OsMPK6 Cascade to Control Spikelet Number by Regulating Cytokinin Metabolism in Rice , Furthermore, overexpression of either DST or OsCKX2 rescued the spikelet number phenotype of the oser1, osmkkk10, osmkk4, and osmpk6 mutants, suggesting that the DST-OsCKX2 module genetically functions downstream of the OsER1-OsMKKK10-OsMKK4-OsMPK6 pathway
- Gn1a~OsCKX2, OsMKK4~LARGE11, ERECTA1 Acts Upstream of the OsMKKK10-OsMKK4-OsMPK6 Cascade to Control Spikelet Number by Regulating Cytokinin Metabolism in Rice , Furthermore, overexpression of either DST or OsCKX2 rescued the spikelet number phenotype of the oser1, osmkkk10, osmkk4, and osmpk6 mutants, suggesting that the DST-OsCKX2 module genetically functions downstream of the OsER1-OsMKKK10-OsMKK4-OsMPK6 pathway
- OsMKK4~LARGE11, OsMPK6~OsMPK4, ERECTA1 Acts Upstream of the OsMKKK10-OsMKK4-OsMPK6 Cascade to Control Spikelet Number by Regulating Cytokinin Metabolism in Rice , Furthermore, overexpression of either DST or OsCKX2 rescued the spikelet number phenotype of the oser1, osmkkk10, osmkk4, and osmpk6 mutants, suggesting that the DST-OsCKX2 module genetically functions downstream of the OsER1-OsMKKK10-OsMKK4-OsMPK6 pathway
- OsMKK4~LARGE11, OsMKKK70, OsMKKK70 regulates grain size and leaf angle in rice through the OsMKK4-OsMAPK6-OsWRKY53 signaling pathway., Biochemical analysis demonstrated that OsMKKK70 is an active kinase and that OsMKKK70 interacts with OsMKK4 and promotes OsMAPK6 phosphorylation
- OsMKK4~LARGE11, OsMKKK70, OsMKKK70 regulates grain size and leaf angle in rice through the OsMKK4-OsMAPK6-OsWRKY53 signaling pathway., Taken together, these findings suggest that OsMKKK70 might regulates grain size and leaf angle in rice by activating OsMAPK6 and that OsMKKK70, OsMKK4, OsMAPK6, and OsWRKY53 function in a common signaling pathway that controls grain shape and leaf angle
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