- Information
- Symbol: OsHRZ1
- MSU: None
- RAPdb: Os01g0689300
- Publication
- Iron-binding Haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation, 2013, Nat Commun.
- Jasmonate signaling is activated in the very early stages of iron deficiency responses in rice roots., 2016, Plant Mol Biol.
- Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice Oryza sativa L.., 2017, Plant Mol Biol.
- Rice HRZ ubiquitin ligases are crucial for response to excess iron., 2018, Physiol Plant.
- Simultaneous Enhancement of iron Deficiency Tolerance and Iron Accumulation in Rice by Combining the Knockdown of OsHRZ Ubiquitin Ligases with the Introduction of Engineered Ferric-chelate Reductase., 2022, Rice (N Y).
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Genbank accession number
- Key message
- Here we report the identification of new iron regulators in rice, designated Oryza sativa Haemerythrin motif-containing Really Interesting New Gene (RING)- and Zinc-finger protein 1 (OsHRZ1) and OsHRZ2
- OsHRZ1, OsHRZ2 and their Arabidopsis homologue BRUTUS bind iron and zinc, and possess ubiquitination activity
- OsHRZ1 and OsHRZ2 are susceptible to degradation in roots irrespective of iron conditions
- These results suggest that OsHRZ1 and OsHRZ2 are iron-binding sensors that negatively regulate iron acquisition under conditions of iron sufficiency
- Many jasmonate-inducible genes were also negatively regulated by the ubiquitin ligases OsHRZ1 and OsHRZ2 and positively regulated by the transcription factor IDEF1
- C1 (OE) rice plants modify the expression of the putative iron-sensing factors OsHRZ1 and OsHRZ2 and enhance the expression of OsIRO2 under copper excess, which suggests a role of copper transport in iron signaling
- Transgenic rice plants with repressed expression of OsHRZ1 and OsHRZ2 (HRZ knockdown lines) are tolerant to low iron availability and accumulate iron in shoots and seeds under both iron-sufficient and -deficient conditions without a growth penalty
- Two iron-binding ubiquitin ligases, OsHRZ1 and OsHRZ2, negatively regulate such iron deficiency responses in rice (Oryza sativa)
- Connection
- OsHRZ1, OsHRZ2, Iron-binding Haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation, Here we report the identification of new iron regulators in rice, designated Oryza sativa Haemerythrin motif-containing Really Interesting New Gene (RING)- and Zinc-finger protein 1 (OsHRZ1) and OsHRZ2
- OsHRZ1, OsHRZ2, Iron-binding Haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation, OsHRZ1, OsHRZ2 and their Arabidopsis homologue BRUTUS bind iron and zinc, and possess ubiquitination activity
- OsHRZ1, OsHRZ2, Iron-binding Haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation, OsHRZ1 and OsHRZ2 are susceptible to degradation in roots irrespective of iron conditions
- OsHRZ1, OsHRZ2, Iron-binding Haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation, These results suggest that OsHRZ1 and OsHRZ2 are iron-binding sensors that negatively regulate iron acquisition under conditions of iron sufficiency
- IDEF1, OsHRZ1, Jasmonate signaling is activated in the very early stages of iron deficiency responses in rice roots., Many jasmonate-inducible genes were also negatively regulated by the ubiquitin ligases OsHRZ1 and OsHRZ2 and positively regulated by the transcription factor IDEF1
- OsHRZ1, OsHRZ2, Jasmonate signaling is activated in the very early stages of iron deficiency responses in rice roots., Many jasmonate-inducible genes were also negatively regulated by the ubiquitin ligases OsHRZ1 and OsHRZ2 and positively regulated by the transcription factor IDEF1
- OsHRZ1, OsHRZ2, Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice Oryza sativa L.., C1 (OE) rice plants modify the expression of the putative iron-sensing factors OsHRZ1 and OsHRZ2 and enhance the expression of OsIRO2 under copper excess, which suggests a role of copper transport in iron signaling
- OsHRZ1, OsIRO2~OsbHLH056, Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice Oryza sativa L.., C1 (OE) rice plants modify the expression of the putative iron-sensing factors OsHRZ1 and OsHRZ2 and enhance the expression of OsIRO2 under copper excess, which suggests a role of copper transport in iron signaling
- OsHRZ1, OsPRI1~OsbHLH115, POSITIVE REGULATOR OF IRON HOMEOSTASIS 1 OsPRI1 positively regulates iron homeostasis in rice., In this study, we reveal that OsPRI1 interacts with OsHRZ1
- OsHRZ1, OsPRI1~OsbHLH115, POSITIVE REGULATOR OF IRON HOMEOSTASIS 1 OsPRI1 positively regulates iron homeostasis in rice., In vitro ubiquitination experiments indicated that OsPRI1 is ubiquitinated by OsHRZ1
- OsHRZ1, OsPRI1~OsbHLH115, POSITIVE REGULATOR OF IRON HOMEOSTASIS 1 OsPRI1 positively regulates iron homeostasis in rice., Cell-free degradation assays revealed that the stability of OsPRI1 decreased in wild type roots, but increased in the hrz1-2 mutant, suggesting OsHRZ1 is responsible for the instability of OsPRI1
- OsHRZ1, OsPRI1~OsbHLH115, POSITIVE REGULATOR OF IRON HOMEOSTASIS 1 OsPRI1 positively regulates iron homeostasis in rice., Collectively, these results imply that OsPRI1, which is ubiquitinated by OsHRZ1, mediates rice responses to Fe-deficiency by positively regulating OsIRO2 and OsIRO3 expression as part of the OsHRZ1-OsPRI1-OsIRO2/3 signal transduction cascade
- OsHRZ1, OsHRZ2, Rice HRZ ubiquitin ligases are crucial for response to excess iron., Two iron-binding ubiquitin ligases, OsHRZ1 and OsHRZ2, negatively regulate such iron deficiency responses in rice (Oryza sativa)
- OsHRZ1, OsHRZ2, Rice HRZ ubiquitin ligases are crucial for response to excess iron., Transgenic rice plants with repressed expression of OsHRZ1 and OsHRZ2 (HRZ knockdown lines) are tolerant to low iron availability and accumulate iron in shoots and seeds under both iron-sufficient and -deficient conditions without a growth penalty
- OsHRZ1, OsHRZ2, Rice HRZ ubiquitin ligases are crucial for response to excess iron., Although the expression of OsHRZ1 and OsHRZ2 is transcriptionally upregulated under iron-deficient conditions, the physiological relevance of this induction is not known
- OsbHLH058~OsPRI2, OsHRZ1, OsbHLH058 and OsbHLH059 transcription factors positively regulate iron deficiency responses in rice., Yeast two-hybrid analysis indicated that OsbHLH058 interacts with OsHRZ1 and OsHRZ2 more strongly than OsbHLH060, whereas OsbHLH059 showed no interaction
- OsbHLH058~OsPRI2, OsHRZ1, OsbHLH058 and OsbHLH059 transcription factors positively regulate iron deficiency responses in rice., An in vitro ubiquitination assay detected no OsbHLH058 and OsbHLH060 ubiquitination by OsHRZ1 and OsHRZ2
- OsbHLH59~OsbHLH059~OsPRI3, OsHRZ1, OsbHLH058 and OsbHLH059 transcription factors positively regulate iron deficiency responses in rice., Yeast two-hybrid analysis indicated that OsbHLH058 interacts with OsHRZ1 and OsHRZ2 more strongly than OsbHLH060, whereas OsbHLH059 showed no interaction
- OsbHLH59~OsbHLH059~OsPRI3, OsHRZ1, Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 OsPRI2 and OsPRI3 are involved in the maintenance of Fe homeostasis., In this study, we identified and functionally characterized OsPRI2 and OsPRI3, two paralogs of OsPRI1, observing that they directly interact with OsHRZ1
- OsbHLH59~OsbHLH059~OsPRI3, OsHRZ1, Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 OsPRI2 and OsPRI3 are involved in the maintenance of Fe homeostasis., Additional analyses suggested that OsHRZ1 promotes the degradation of OsPRI2 and OsPRI3
- OsHRZ1, OsIMA1, IRONMAN peptide interacts with OsHRZ1 and OsHRZ2 to maintain Fe homeostasis in rice., Here, we reveal that OsIMA1 and OsIMA2 interact with the potential Fe sensors, OsHRZ1 (HAEMERYTHRIN MOTIF-CONTAINING REALLY INTERESTING NEW GENE (RING) AND ZINC-FINGER PROTEIN 1) and OsHRZ2
- OsHRZ1, OsIMA1, IRONMAN peptide interacts with OsHRZ1 and OsHRZ2 to maintain Fe homeostasis in rice., OsIMA1 and OsIMA2 contain a conserved 17 amino acid C-terminal region which is responsible for the interactions with OsHRZ1 and OsHRZ2
- OsHRZ1, OsIMA1, IRONMAN peptide interacts with OsHRZ1 and OsHRZ2 to maintain Fe homeostasis in rice., Co-expression assays suggest that OsHRZ1 and OsHRZ2 promote the degradation of OsIMA1 proteins
- OsHRZ1, OsIMA2, IRONMAN peptide interacts with OsHRZ1 and OsHRZ2 to maintain Fe homeostasis in rice., Here, we reveal that OsIMA1 and OsIMA2 interact with the potential Fe sensors, OsHRZ1 (HAEMERYTHRIN MOTIF-CONTAINING REALLY INTERESTING NEW GENE (RING) AND ZINC-FINGER PROTEIN 1) and OsHRZ2
- OsHRZ1, OsIMA2, IRONMAN peptide interacts with OsHRZ1 and OsHRZ2 to maintain Fe homeostasis in rice., OsIMA1 and OsIMA2 contain a conserved 17 amino acid C-terminal region which is responsible for the interactions with OsHRZ1 and OsHRZ2
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